Increased Krüppel-like factor 12 in recurrent implantation failure impairs endometrial decidualization by repressing Nur77 expression
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چکیده
منابع مشابه
Increased Krüppel-like factor 12 in recurrent implantation failure impairs endometrial decidualization by repressing Nur77 expression
BACKGROUND Decidualization is a prerequisite for successful implantation and the establishment of pregnancy. A critical role of impaired decidualization in subfertility has been established. In human endometrial stromal cells (hESCs), Krüppel-like factor 12 (KLF12) and Nur77 are novel regulators of decidualization. We investigated whether KLF12 impaired the decidualization of hESCs in recurrent...
متن کاملMicroRNA-181a is involved in the regulation of human endometrial stromal cell decidualization by inhibiting Krüppel-like factor 12
BACKGROUND The transformation of endometrium into decidua is essential for normal implantation of the blastocyst. However, the post-transcriptional regulation and the miRNAs involved in decidualization remain poorly understood. Here, we examined microRNA-181a (miR-181a) expression in decidualized human endometrial stromal cell (hESC). In addition, we investigated the functional effect of miR-18...
متن کاملKrüppel-like factor 12 is a novel negative regulator of forkhead box O1 expression: a potential role in impaired decidualization
BACKGROUND Decidualization is a prerequisite for successful implantation and the establishment of pregnancy. Krüppel-like factor 12 (KLF12) is a negative regulator of endometrial decidualization in vitro. We investigated whether KLF12 was associated with impaired decidualization under conditions of repeated implantation failure (RIF). METHODS Uterine tissues were collected from a mouse model ...
متن کاملI-24: Recurrent Implantation Failure
Recurrent implantation failure (RIF) has many definitions, but usually authors consider RIF, the failure to achieve a pregnancy fallowing 2-6 IVF cycles in which more than 10 high grade embryos were transferred to the uterus. There are a lot of causes for RIF but two main causes of that are related to embryo and endometrium. Chromosomal abnormalities, zona hardening and problems in culture medi...
متن کاملRegulation of corneal keratin-12 gene expression by the human Krüppel-like transcription factor 6.
PURPOSE The keratin-12 (K12) protein is essential for the integrity of the corneal epithelium. This study was conducted to investigate the possible involvement of Krüppel-like factor 6 (KLF6) in the corneal regulation of K12 gene expression, in view of the presence of one KLF6 potential binding site in the human K12 promoter and the known role of KLF6 in regulating keratin gene expression. ME...
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ژورنال
عنوان ژورنال: Reproductive Biology and Endocrinology
سال: 2017
ISSN: 1477-7827
DOI: 10.1186/s12958-017-0243-8